Page 19 - Cashew healthy book-2023

Cashew is Healthy for the Entire Family

No Difference in Health-Related Quality of Life,

After a Food Challenge with Cashew Nut in

Children Participating in a Clinical Trial

Cashew and Children

Author(s): J. P. M. van der Valk, R. Gerth van Wijk, B. M. J. Flokstra-de Blok,
J. L. van der Velde, H. de Groot, H. J. Wichers, A. E. J. Dubois, N. W. de Jongt

Author Affiliation
• Department Of Internal Medicine, Allergology, Erasmus MC, Rotterdam,
The Netherlands.
• Department of Pediatric Allergology, Diaconessenhuis Voorburg, RdGG,
Delft, The Netherlands.
• Wageningen UR Food & Biobased Research, Wageningen, The Nether-
lands.
• Department of Pediatric Pulmonology and Pediatric Allergology, GRIAC
Research Institute; Department of General Practice,University Medical
Centre Groningen, University of Groningen, Groningen, The Netherlands.

First published: 06 August 2016 https://doi.org/10.1111/pai.12621Citations: 10

Background
Previous studies showed that health-related quality of life (HRQL) significantly
improved after the food challenge, with greater improvements in HRQL after
a negative outcome than after a positive outcome. It is currently unknown
whether this also occurs in patients undergoing DBPCFCs with cashew nut in
the context of a clinical trial. Conclusion
This study showed no difference in
Methods: Quality of life was studied in children enrolled in a cashew nut study the change in HRQL scores after a
using Food Allergy Quality of Life Questionnaires (FAQLQs). Children, teen- DBPCFC with cashew nut in chil-
agers and parents of the children completed the questionnaires before the dren participating in a clinical trial.
challenge test and 6 months after the DBPCFC with cashew nut. The differ- The utility of HRQL as an outcome
ence in the change in HRQL between the children with a positive and negative for clinical trials in food allergy may
DBPCFC outcome was studied by Mann–Whitney U-test.
be limited if participant baseline
HRQL is relatively unimpaired.
Results: In total, 112 children (67 boys, median age of 9 years) were includ-
ed. The children, teenagers and parents of the children completed 143 sets
of questionnaires in total. There were no significant differences in baseline
total and domain scores compared to the follow-up scores in the FAQLQ-CF,
FAQLQ-TF and FAQLQ-PF. In children, the delta FAIM score in the negative
DBPCFC tested group was significantly better than the delta FAIM score in the
positive challenged group (p = 0.026). There were no significant differences
in the changes in the scores of the FAQLQ-CF and FAQLQ-PF in the children
with a positive challenge outcome, compared to the children with a negative
challenge result. However, there was a significant difference in the change in
score between the latter groups in the domain ‘accidental exposure’ of the
FAQLQ-TF (p = 0.049).

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